Novel injectable suspension delivers ongoing efficacy against fleas and ticks for dogs six months and older in a single dose
MADISON, N.J., May 1, 2023 – MSD Animal Health, a division of Merck & Co., Inc., Rahway, N.J., USA (NYSE:MRK), today announced that the Australian Pesticides and Veterinary Medicines Authority (APVMA) has approved a novel injectable formulation of BRAVECTO® (fluralaner) for the treatment and prevention of flea (Ctenocephalides felis) infestations for 12 months, control of paralysis tick (Ixodes holocyclus) for 12 months, control of brown dog tick (Rhipicephalus sanguineus) for 11 months and control of flea allergy dermatitis (FAD). BRAVECTO QUANTUM™ is indicated for use by or under the supervision of a veterinarian and for administration to dogs and puppies from six months of age.
The Company is working with the appropriate regulatory bodies to make the product available in markets around the world.
“Since our initial launch of BRAVECTO, nearly a decade ago, MSD Animal Health has been committed to bringing innovations to our customers that protect pets longer from flea and tick-borne illnesses,” said Rick DeLuca, president, MSD Animal Health. “With the approval of the first and only once-yearly injectable flea and paralysis tick medication, pet owners now have a new, convenient option for comprehensive protection to help keep their pets protected year-round from fleas and paralysis ticks without the need for administering multiple doses of medication.”
Of the tick species in Australia, brown dog tick and paralysis tick are two of the most dangerous as they can transmit serious infections, cause paralysis, and may even play a role in the transmission of emerging human health-threatening pathogens, such as Q fever (caused by the bacteria Coxiella burnetii). Brown dog tick, the most widespread tick in tropical and sub-tropical areas of Australia, and paralysis tick, another common tick in the country, can live in both warm and cold temperatures and are known to feed on pet dogs.[i] Certain flea and tick species also can thrive in various temperatures and seasons, making continuous year-round protection of utmost importance for pets and people.
BRAVECTO QUANTUM takes 3 days to exert its full effect, so it should be applied at least 3 days before the dog is exposed to paralysis ticks. Ticks already on dogs prior to applying BRAVECTO QUANTUM will not be killed immediately after injection. These ticks should be removed.
“Though we typically think of flea and tick season during the summer months, studies have shown that while fleas and ticks are most active from early spring through the fall, fleas and brown dog ticks infest homes and can be a threat year-round,” said Jason Drake, DVM, DACVM-Parasitology, director, scientific marketing affairs, Companion Animal Parasiticides, MSD Animal Health. “With a once-yearly dosing, BRAVECTO QUANTUM can provide a long duration of protection, simplifying flea and tick protection for both pet owners and veterinarians, which promotes compliance and helps ensure continuous protection.”
The active ingredient in BRAVECTO QUANTUM is fluralaner, an isoxazoline that has been prescribed by veterinarians to protect dogs from fleas and ticks since 2014. The unique crystallized fluralaner in suspension is gradually absorbed from the site of the injection, providing ongoing efficacy against fleas and ticks for up to 12 months. There are no contraindications to administering the product with other commonly used medications and vaccinations.
BRAVECTO QUANTUM is well tolerated with the only treatment-related finding limited to transient, non-painful injection site swellings that resolved over time, with no further treatment required.
Fluralaner is part of the isoxazoline family of chemicals. Adverse reactions to this family of chemicals are rarely observed but may include vomiting, diarrhoea, lethargy, inappetence, itching and very rarely, seizures. Most adverse reactions are self-limiting and of short duration.
About BRAVECTO® (fluralaner)
Since its introduction in 2014, BRAVECTO has provided longer-lasting flea and tick protection, with more than 300 million doses distributed in 85 countries. BRAVECTO is available in a variety of formulations, including products for both dogs and cats.
The flea and tick lifecycles can also last for months and missed doses of monthly treatments may leave gaps in protection.
Providing pets with continuous flea and tick protection is essential – whether the pet goes outside or not. Contrary to popular belief among pet parents, fleas and ticks are not only active in the spring and summer months and are a year-round risk.
Fleas and ticks can easily latch onto dogs and cats, and can spread serious diseases, including tapeworms and Lyme disease. They also can bite and pose health risks to human family members whether at home or outdoors. Fleas are the most common external parasite found on pets.
About MSD Animal Health
At MSD, known as Merck & Co., Inc., Rahway, N.J., USA in the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. For more than a century, we’ve been at the forefront of research, bringing forward medicines, vaccines and innovative health solutions for the world’s most challenging diseases. MSD Animal Health, a division of Merck & Co., Inc., Rahway, N.J., USA, is the global animal health business of MSD. Through its commitment to The Science of Healthier Animals®, MSD Animal Health offers veterinarians, farmers, pet owners and governments one of the widest ranges of veterinary pharmaceuticals, vaccines and health management solutions and services as well as an extensive suite of connected technology that includes identification, traceability and monitoring products. MSD Animal Health is dedicated to preserving and improving the health, well-being and performance of animals and the people who care for them. It invests extensively in dynamic and comprehensive R&D resources and a modern, global supply chain. MSD Animal Health is present in more than 50 countries, while its products are available in some 150 markets. For more information, visit www.msd-animal-health.com and connect with us on LinkedIn and Twitter.
Forward-Looking Statement of Merck & Co., Inc., Rahway, N.J., USA
This news release of Merck & Co., Inc., Rahway, N.J., USA (the “company”) includes “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company’s management and are subject to significant risks and uncertainties. There can be no guarantees with respect to pipeline candidates that the candidates will receive the necessary regulatory approvals or that they will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.
Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of the global outbreak of novel coronavirus disease (COVID-19); the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions.
The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company’s Annual Report on Form 10-K for the year ended December 31, 2022 and the company’s other filings with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site (www.sec.gov).
 Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, et al. Human tick-borne diseases in Australia. Front Cell Infect Microbiol. 2019 Jan 28;9:3.